mRNA vaccines and Neurodegenerative Disease

I took this information and cut and pasted it for an easier read. Just so you can get an idea. I could easily have added 300 articles presenting excellent research and reasoning on mRNA vaccines. Only one area is covered here below; the nerves. I used this article as these new Rabies vaccines target the nerves in the recipients. You don't have to digest it all, it's just to see that there are literally thousands of articles out there that are well researched by expert scientists. 

SARS-COV-2 Vaccines and Neurodegenerative Disease
By Stephanie Seneff and GreenMedInfo January 11, 2022 Updated: January 12, 2022

These vaccines had been developed “at warp speed,”  for the COVID-19 pandemic.

There were four different vaccines that have been approved for emergency use for protection against COVID-19 [which they did not do as later studies revealed] in the US and/or Europe. Two (the Moderna vaccine and the Pfizer/BioNTech vaccine) are based on mRNA technology, whereas the other two (produced by Johnson & Johnson and AstraZeneca) are based on a double-stranded DNA recombinant viral vector. The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. 

People don’t realize that these vaccines are vastly different from the many childhood vaccines we are now used to getting early in life. I found it shocking that the vaccine developers and the government officials across the globe are wrecklessly pushing these vaccines on an unsuspecting population.  Knowing how these vaccines work, how the immune system works and how neurodegenerative diseases come about can be brought to bear on the problem in order to predict potential devastating future consequences of the vaccines.

The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. Additional ingredients like cationic lipids and polyethylene glycol are also toxic with unknown consequences. The vaccines were approved for emergency use based on grossly inadequate studies to evaluate safety and effectiveness.

Our paper showed that there are several mechanisms by which these vaccines could lead to severe disease, including autoimmune disease, neurodegenerative diseases, vascular disorders (hemorrhaging and blood clots) and possibly reproductive issues. 

Like the mRNA vaccines, the DNA vaccines are based on novel biotech gene editing techniques that are brand new, so they too are a massive experiment unleashed on a huge unsuspecting population, with unknown consequences. Both DNA vector vaccines have been associated with a very rare condition called thrombocytopenia, in which platelet counts drop precipitously, resulting in system-wide blood clots and a high risk of cerebral hemorrhaging . This is likely due to an autoimmune reaction to the platelets, and it comes with a high risk of mortality. In the case of the AZ vaccine, this has caused over 20 European countries to temporarily pause their vaccination programs. And the United States called a temporary halt on the J&J vaccine.

Even experts don’t really understand the mechanism as of now, although a fascinating theory to explain this depends on the fact that DNA vector vaccines require the DNA to be copied into RNA in the nucleus, and this presents the possibility of producing an incomplete copy, generated through “splice variants,” that is missing the code for attaching to the membrane. These soluble partial sequences wander off to other parts of the body and bind to ACE2 receptors throughout the vasculature. Antibodies to these ACE2-bound partial spike fragments cause an acute inflammatory response that results in disseminated intravascular coagulation (DIC).


The Spike Protein is Toxic

The COVID-19 vaccines are all based on supplying genetic code to produce the spike protein that is the main constituent of the SARS-CoV-2 protein cage that encloses its RNA contents. Both the DNA vector and the RNA vaccines induce the vaccine-infected cell to manufacture many copies of the spike protein according to the code. Through experimentation, researchers have determined that the spike protein is toxic even when introduced all by itself. In a revealing experiment, researchers injected spike protein into hamsters, and found that it was taken up by endothelial cells lining the blood vessels, via ACE2 receptors. This caused a downregulation of ACE2, which had significant effects on the metabolic policy in the cells. In particular, it inhibited the synthesis of mitochondria, and caused the existing mitochondria to fragment. Mitochondria are the organelles in the cell that produce large quantities of ATP (the energy currency of cells) by oxidizing nutrients, while consuming oxygen and producing water and carbon dioxide. The spike protein reduced the production of ATP by mitochondria and increased glycolysis — the alternative, much less efficient, way to produce ATP without using oxygen. This metabolic change towards getting energy through glycolysis is a characteristic feature of cancer cells and of neurons in neurodegenerative diseases such as Alzheimer’s.

In another experiment, researchers showed that spike protein can cross the blood-brain barrier in mice and be taken up by neurons throughout the brain. This too is likely mediated by ACE2 receptors (which neurons also produce). These same researchers also showed that spike protein administered in the nose was able to reach the brain by traveling along the olfactory nerve. When they induced inflammation in the brain through exposure to lipopolysaccharide (LPS), they saw an increased uptake of spike protein into the brain, which they hypothesized was caused by increased leakiness in the barrier. As you will see, these points become important when we later consider what happens following a SARS-CoV-2 vaccine, which is designed to induce inflammation.

A published preprint found widespread expression of ACE2 in many parts of the brain. ACE2 was expressed in astrocytes, pericytes (cells that wrap around the endothelial cells lining capillary walls) and in endothelial cells — and all of these are key components of the blood-brain barrier. Perhaps of even greater concern is that ACE2 was highly expressed in the substantia nigra, a brain-stem nucleus where damaged dopaminergic neurons lead to Parkinson’s disease.

Bell’s Palsy

The mRNA vaccines appear to disrupt the body’s ability to keep latent viruses from “waking up” and causing disease symptoms. This observation is based on the fact that shingles and facial palsy (Bell’s palsy) are being commonly reported in side-effect reports in the FDA’s Vaccine Adverse Event Reporting System. As of May 21, 2021, over 2500 reports of Bell’s palsy following COVID-19 vaccines had appeared in VAERS. A primary cause of Bell’s palsy is the activation of latent viral infections, most notably Herpes simplex and Varicella zoster, Varicella zoster is also the virus responsible for shingles.


 

Prion Diseases

Prion diseases are a group of severe neurodegenerative diseases that are caused by misfolded prion proteins. The most common prion disease in humans is the always-fatal sporadic Creutzfeldt-Jakob disease (CJD), which accounts for more than 85% of the cases. Prion diseases are more specifically called transmissible spongiform encephalopathies (TSEs), and infection can spread through exposure to misfolded proteins as “infective” agents, without requiring a live pathogen. PrP is the name given to the specific prion protein associated with these TSEs. Misfolded PrP proteins act as a seed or catalyst that then recruits other molecules of PrP to misfold in the same way and glom together into pathogenic fibrils.

MADCOW, the disease that affected a large number of cows in Europe beginning in the 1990s, is probably the best-known TSE. While eating beef from an infected animal is a very rare risk factor, most cases of Creutzfeldt-Jakob disease occur for unknown reasons, and no other risk factors have been identified. A study based in Switzerland confirmed that many patients who died of Creutzfeldt-Jakob disease had detectable levels of a prion protein in their spleen and muscles, in addition to the olfactory lobe and the central nervous system. More generally, diseases involving misfolded PrPs have consistently been found to involve an initial early phase of prion replication in the spleen which happens long before overt symptoms appear. This point becomes important when we consider whether the COVID-19 vaccines might cause prion diseases.


Many neurodegenerative diseases have been linked to specific proteins that have prion-like properties, and these diseases are characterized as protein-misfolding diseases or proteopathies. Like PrP, prion-like proteins become pathogenic when their alpha helices misfold as beta sheets, and the protein is then impaired in its ability to enter the membrane. These diseases include Alzheimer’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease and Parkinson’s disease, and each of these is associated with a particular protein that misfolds and accumulates in inclusion bodies in association with the disease. We already saw that Parkinson’s disease is characterized by Lewy bodies in the substantia nigra that accumulate misfolded α-synuclein.

Tracing the Vaccine Trail to the Spleen

It is important to understand what happens to the contents of a vaccine after it is injected into the arm. Where does it travel in the body, and what does it do in the places where it settles in?

Vaccine developers are keen to know whether the vaccine induces a strong immune response, reflected in high antibody production against the spike protein, in the case of COVID-19 vaccines. And to do this, they need to trace its movement in the body.

The vaccine is picked up by antigen-presenting cells at the injection site and carried to the spleen via the lymph system. The carrier cells then hang out in the spleen for a long time. And this is where the danger lies in terms of the potential to cause prion disease.

In the paper that Greg Nigh and I published recently on the mRNA vaccines, we argued that the mRNA vaccines are rather perfectly set up to produce a very dangerous situation in the spleen that is poised to launch a prion disease. Given the fact that the DNA vector vaccines also end up concentrated in the spleen, I think that the same thing holds true for them as well. The spleen is where the action is for seeding misfolded prion proteins. The vaccine-infected cells have been programmed to produce large amounts of spike proteins. Prion proteins misfold into damaging beta-sheet oligomers when there are too many of them in the cytoplasm. Might the spike protein do the same?

Germinal Centers in the Spleen

Germinal centers in the spleen are a primary factory where antibodies against specific antigens (such as the spike protein) are manufactured and perfected. Makers of the mRNA vaccines were pleased to see that antigen-presenting cells (mainly dendritic cells), originally attracted to the site of the injection, take up the mRNA particles and then migrate via the lymph system to the spleen in high numbers and induce high levels of antibody production in these germinal centers.

Unfortunately, these same germinal centers are a primary site for the initiation of a process of producing and distributing misfolded prion proteins, often seeded by viral proteins, and triggered by an acute inflammatory response
 

Summary

There are many reasons to be wary of the COVID-19 vaccines, which have been rushed to market with grossly inadequate evaluation and aggressively promoted to an uninformed public, with the potential for huge, irreversible, negative consequences. One potential consequence is to exhaust the finite supply of progenitor B cells in the bone marrow early in life, causing an inability to mount new antibodies to infectious agents. An even more worrisome possibility is that these vaccines, both the mRNA vaccines and the DNA vector vaccines, may be a pathway to crippling disease sometime in the future. Through the prion-like action of the spike protein, we will likely see an alarming increase in several major neurodegenerative diseases, including Parkinson’s disease, CKD, ALS and Alzheimer’s, and these diseases will show up with increasing prevalence among younger and younger populations, in years to come. Unfortunately, we won’t know whether the vaccines caused this increase, because there will usually be a long time separation between the vaccination event and the disease diagnosis. Very convenient for the vaccine manufacturers, who stand to make huge profits off of our misfortunes — both from the sale of the vaccines themselves and from the large medical cost of treating all these debilitating diseases.

Stephanie Seneff is a Senior Research Scientist at the MIT Computer Science and Artificial Intelligence Laboratory. She received the B.S. degree in Biophysics in 1968, the M.S. and E.E. degrees in Electrical Engineering in 1980, and the Ph.D degree in Electrical Engineering and Computer Science in 1985, all from MIT. For over three decades, her research interests have always been at the intersection of biology and computation: developing a computational model for the human auditory system, understanding human language so as to develop algorithms and systems for human computer interactions, as well as applying natural language processing (NLP) techniques to gene predictions. She has published over 170 refereed articles on these subjects, and has been invited to give keynote speeches at several international conferences. She has also supervised numerous Master’s and PhD theses at MIT. In 2012, Dr. Seneff was elected Fellow of the International Speech and Communication Association (ISCA).

Originally published on GreenMedInfo.com